Ronan Feighery
Biobank Manager at St. James's Hospital/Trinity College
- Location
- Ireland
- Industry
- Research
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Ronan Feighery's Overview
- Current
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- Biobank Manager at St. James's Hospital/Trinity College
- Past
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- Research scientist at Sekisui Medical, Japan
- Education
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- University College Dublin
- University College Dublin
- Connections
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30 connections
Ronan Feighery's Summary
I am currently working in the Department of Surgery in St. James's Hospital as the Biobank Manager. The role has given me an insight to public healthcare system through daily interaction with the surgical team, recruitment of patients for a national research study and the database work required for cataloguing biological samples and patient surveillance. I am also involved in several ongoing research projects in the department, with a particular focus on oesophageal cancer and Barrett's Oesophagus.
Prior to this, I worked in the R&D department of Japan's largest CRO, Sekisui Medical, just outside Tokyo for 2 years. My main research project involved identification of human-specific metabolites formed by hepatotoxicants following administration to chimeric PXB mice. I also prepared scientific information leaflets for marketing and promotional use, and kept up-to-date on new research papers relevant to Sekisui’s interests and new services offered by competitors. Furthermore, I also dealt with international pharmaceutical companies regarding licensing agreements and pricing.
In 2008, I successfully completed my PhD thesis in the Conway Institute, UCD, which was based on a phenomenon known as epithelial-mesenchymal transition (EMT) and the role this plays in the pathogenesis of renal fibrosis, focusing on the proteins involved therein. Previously, I graduated in 2004 with a BSc (Hons) in Pharmacology.
Ronan Feighery's Experience
Biobank Manager
St. James's Hospital/Trinity College
Nonprofit; 1001-5000 employees; Hospital & Health Care industry
February 2011 – Present (2 years 5 months)
Since returning to Ireland, I have been working as the biobank manager in the Department of Surgery, St. James’s Hospital. The role has given me an insight to public healthcare system through daily interaction with the surgical team, recruitment of patients for a national research study where human blood and tissue samples are stored for translational research projects, along with the database work required for cataloguing biological samples and patient surveillance. I also prepared the successful ethics applications, and oversee the project management, for the Barrett’s biobanks in St. James’s, St. Vincent’s, Beaumont and the Mater hospitals. Because this is a multi-site project, my role involves travel to the other sites to assist with biobanking/database problems and transportation of biological samples. I am also involved in several ongoing research projects in the department, with a particular focus on oesophageal cancer and preparing lectures for the MSc course in Translational Oncology.
Research scientist
Sekisui Medical, Japan
February 2009 – January 2011 (2 years) Tokai, Ibaraki, Japan
I was a member of the Research & Development department.
My main research project involved structural elucidation and identification of human-specific metabolites formed by hepatotoxicants following administration to chimeric PXB mice, a novel animal model, in which more than 70% of hepatic parenchymal cells are replaced by human hepatocytes. In 2008, the FDA issued the Guidance of Safety Testing of Drug Metabolites which recommended the evaluation of human-specific metabolites, or metabolites that are present at disproportionately higher levels in humans compared with any of the animal species used during standard non-clinical toxicology testing. It is hoped that my work will help to establish chimeric PXB mice as an FDA-approved pre-clinical animal model. My other research project was the investigation of the role played by hepatic drug transporters, which was in collaboration with Prof. Sugiyama of Tokyo University, who co-authored the concept paper, along with several scientists from the FDA, published by the International Transporter Consortium in March 2010.
•As Sekisui Medical is Japan’s largest CRO, I performed contract research services involving hepatic transporters, mostly involving DMPK studies.
•Preparation of scientific information leaflets for marketing and promotional use.
•Keep sales team informed of new research papers relevant to Sekisui’s interests and new services offered by competitors.
•Continual monitoring of changes to FDA guidelines regarding transporters, drug metabolism and pharmacokinetics.
•Preparation of SOPs.
•Inspection of all English reports for contract services prior to sending to clients.
•Negotiating with American companies regarding licensing agreements and pricing.
•Liaising with Sekisui Medical’s American subsidiary, Xenotech, on numerous issues.
Ronan Feighery's Honors and Awards
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Travel Scholarship (2007)
European Renal Cell Study Group- March 2007
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Finalist in UCD Access Science
- February 2007
This is a highly publicised annual competition, chaired by Pat Kenny. Six finalists (PhD students) give oral presentations based on their research to a large non-scientific audience, without using any scientific jargon.
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President of UCD Pharmacology and Toxicology Society
- 2005
Responsibilities included targeting and contacting speakers for pharmaceutical research/industry seminars, chairing seminars, fundraising and budgeting.
Ronan Feighery's Publications
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Feighery R, Maguire P, Ryan MP, McMorrow T. A proteomic approach to immune-mediated epithelial-mesenchymal transition. Proteomics-Clinical Applications. 2008; 2: 1110-1117.
- Proteomics-Clinical Applications
- 2008
Authors: Ronan Feighery -
Feighery R, Maguire P, Ryan MP, McMorrow T. Proteomic approaches to immune-mediated epithelial-mesenchymal transition (EMT) in renal disease. 2008; 18: SA-PO126.
- J Am Soc Nephrol
- 2008
Authors: Ronan Feighery -
Lynch J, Nolan S, Slattery C, Feighery R, Ryan MP, McMorrow T. HMGB-1 - A novel mediator of inflammatory-induced renal epithelial mesenchymal transition. Am J Nephrol, 2010; 32(6):590-602.
- Am J Nephrol
- 2010
Authors: Ronan Feighery -
Quinn T, Feighery R, Baird A. Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction. Eur J Pharmacol., 2006; 534(1-3):210-7.
- Eur J Pharmacol
- 2006
Authors: Ronan Feighery
Ronan Feighery's Languages
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Japanese
(Professional working proficiency) -
English
(Native or bilingual proficiency)
Ronan Feighery's Skills & Expertise
Ronan Feighery's Education
University College Dublin
Doctor of Philosophy (PhD), Molecular Biology
2004 – 2008
“A proteomic approach to immune-mediated epithelial-mesenchymal transition (EMT) in renal toxicology and disease development”
My thesis was based on a phenomenon known as epithelial-mesenchymal transition (EMT) and the role this plays in the pathogenesis of renal fibrosis. The aim of this study was to investigate the proteome of renal tubular epithelial cells undergoing EMT in vitro. The human proximal tubular cell line (HK-2), exposed to conditioned medium from activated peripheral blood mononuclear cells (PBMC-CM), underwent a phenotypic change, from an epithelial towards a fibroblastic, or mesenchymal, phenotype. Using extensive proteomic analysis, I identified several proteins, including interleukin-6, which could play key roles in immune-mediated EMT.
•Planned, organised and supervised two final year BSc (Pharmacology) students in the successful completion of final year projects.
University College Dublin
BSc Honours, Pharmacology
2000 – 2004
Grade: Second Class Honour (Grade I)
During my final undergraduate year, I spent 5 months in the Department of Veterinary Physiology and Biochemistry, University College Dublin, under the supervision of Prof. Alan Baird, in which time I completed a project entitled ‘Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction’, which was later published.
Quinn T, Feighery R, Baird A. Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction. Eur J Pharmacol., 2006; 534(1-3):210-7.
Ronan Feighery's Additional Information
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